Stephen J. Coales, Sook Yen E, Jessica E. Lee, Anita Ma,
Jeffrey A. Morrow, and Yoshitomo Hamuro “Expansion of Time Window for Mass
Spectrometric Measurement of Amide Hydrogen/Deuterium Exchange Reactions” Rapid
Communications in Mass Spectrometry 2010, 24, 3584-3592
Hal A. Lewis, Chi Wang,
Xun Zhao, Yoshitomo
Hamuro, Kristine Conners, Margaret C.
Kearins, F. Lu, J. Michael
Sauder, Kathleen S. Molnar,
Stephen J. Coales,
Peter C. Maloney,
William B. Guggino, Diana R. Wetmore, Patricia C. Weber, and
John F. Hunt “Structure and Dynamics of NBD1 from CFTR
Characterized Using Crystallography and Hydrogen-Deuterium Exchange Mass
Spectrometry
” Journal of Molecular Biology
2010, 396, 406-430
Gerhardt S, Abbott WM, Hargreaves D, Pauptit RA,
Davies RA, Needham MR, Langham C, Barker W, Aziz A, Snow MJ, Dawson S,
Welsh F, Wilkinson T, Vaugan T, Beste G, Bishop S, Popovic B, Rees G,
Sleeman M, Tuske SJ, Coales SJ, Hamuro Y, Russell C. “Structure of IL-17A in Complex with a Potent, Fully Human
Neutralizing Antibody” Journal of
Molecular Biology 2009 Dec 18;394(5):905-21. Epub 2009 Oct 14.
Kathleen S. Molnar, Qi Wang, N. Murat Karabacak, Ashutosh Tiwari, Lawrence J.
Hayward, Stephen J. Coales, Yoshitomo Hamuro, Jeffrey N. Agar “A common property
of amyotrophic lateral sclerosis-associated variants: Destabilization of the
Cu/Zn superoxide dismutase electrostatic loop” Journal of Biological Chemistry 2009, 284,
30965-30973
Maegawa GH, Tropak MB, Buttner JD, Rigat BA, Fuller M, Pandit D, Tang L, Kornhaber GJ, Hamuro, Y, Clarke JT, Mahuran DJ "Identification and characterization of Ambroxol as an enzyme enhancement agent for Gaucher disease"
J Biol Chem 2009, 284, 23502-23516
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Sharma S, Zheng H, Huang YJ, Ertekin A, Hamuro Y, Rossi P, Tejero R, Acton TB, Xiao R, Jiang M, Zhao L, Ma LC, Swapna GV, Aramini JM, Montelione GT "Construct optimization for protein NMR structure analysis using amide hydrogen/deuterium exchange mass spectrometry"
Proteins 2009, 76, 882-894
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Stephen J. Coales, Steven J. Tuske, Justine C. Tomasso, and Yoshitomo Hamuro “Epitope Mapping by Amide Hydrogen/Deuterium Exchange Coupled with Proteolysis and Liquid Chromatography Mass Spectrometry”
Rapid Communications in Mass Spectrometry 2009 Mar;23(5):639-47. click here
Vikas Chandra, Pengxiang Huang, Yoshitomo Hamuro, Srilatha Raghuram, Yongjun Wang, Thomas P. Burris, Fraydoon Rastinejad "Structural Organization of the Intact PPARγ-RXRα Nuclear Receptor Complex on DNA"
Nature 2008 Nov 20;456(7220):350-6
click hereMichael B. Tropak, Gregory Kornhaber, Brigitte Rigat, Gustavo Maegawa, Justin Buttner, Jan Blanchard, Cecilia Murphy, Steven J. Tuske, Stephen J. Coales, Yoshitomo Hamuro, Eric Brown, Don Mahuran "Identification of Pharmacological Chaperones for Gaucher Disease and Characterization of their Effects on b-Glucocerebrosidase by Hydrogen/Deuterium Exchange Mass Spectrometry"
ChemBioChem 2008 Nov 3;9(16):2650-62 click here
Gregory J. Kornhaber, Michael B. Tropak, Gustavo Maegawa, Stephen J. Tuske, Stephen J. Coales, Don J. Mahuran, Yoshitomo Hamuro "Isofagomine Induced Stabilization of Glucocerebrosidase"
ChemBioChem 2008 Nov 3;9(16):2643-9 click here
Yoshitomo Hamuro, Justine C. Tomasso, and Stephen J. Coales "A Simple Test to Detect Hydrogen/Deuterium Scrambling during Gas Phase Peptide Fragmentation"
Anal. Chem.
2008 Sep 1;80(17):6785-90. Epub 2008 Jul 31 click here
Yoshitomo Hamuro, Lora L. Hamuro, Stephen J. Coales, and Virgil L. Woods Jr. "Use of Enhanced Peptide Amide Hydrogen/Deuterium Exchange-Mass Spectrometry (DXMS) in the Examination of Protein-Protein Interactions" in
Mass Spectrometry Analysis for Protein-Protein Interactions and Dynamics. Mark Chance Ed., Blackwell, in press.
Lusong Luo, Jeffrey D. Carson, Kathleen S. Molnar, Steven J. Tuske, Stephen J. Coales, Yoshitomo Hamuro, Chiu-mei Sung, Valery Sudakin, Kurt R. Auger, Dashyant Dhanak, Jeffrey R. Jackson, Pearl S. Huang, Peter J. Tummino, Robert A Copeland "Conformation-Dependent Ligand Regulation of ATP Hydrolysis by human KSP: Activation of Basal Hydrolysis and Inhibition of Microtubule-Stimulated Hydrolysis by a Single, Small Molecule Modulator"
J. Am. Chem. Soc 2008, 130, 7584-7591.
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Michael C. Schuster, Krisztián Papp, Kathleen S. Molnar, Stephen J. Coales, Yoshitomo Hamuro, Georgia Sfyroera, Hui Chen, Michael S. Winters, and John D. Lambris, "Dynamic Structural Changes During Complement C3 Activation Analyzed by Hydrogen/Deuterium Exchange Mass Spectrometry"
Mol. Immunology 2008, 45, 3142-3151.
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Stephen J. Coales, Justine C. Tomasso, and Yoshitomo Hamuro "Effects of Electrospray Capillary Temperature on Amide Hydrogen Exchange"
Rapid Communications in Mass Spectrometry 2008, 22, 1367-1371.
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Yoshitomo Hamuro, Stephen J. Coales, Kathleen S. Molnar, Steven J. Tuske, Jeffrey A. Morrow "Specificity of Immobilized Porcine Pepsin in H/D Exchange Compatible Conditions" Rapid
Communications in Mass Spectrometry 2008, 22, 1041-1046.
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Yoshitomo Hamuro, Kathleen S. Molnar, Stephen J. Coales, Bo Ou Yang, Alana Simorellis, and Thomas C. Pochapsky "Hydrogen-Deuterium Exchange Spectrometry for Investigation of Backbone Dynamics of Oxidized and Reduced Cytochrome P450cam" J. Inorg. Biochem. 2008, 102, 364.
Yoshitomo Hamuro, Stephen J. Coales, and Virgil L. Woods Jr. "Protein-Targeting Drug Discovery Guided by Hydrogen/Deuterium Exchange Mass Spectrometry (DXMS)" in Mass Spectrometry in
Medicinal Chemistry. Klaus T. Wanner Ed., Wiley-VCH, 2007.
Yoshitomo Hamuro, Stephen J. Coales, Jeffrey A. Morrow, Patrick R. Griffin, Mark R. Southern, and Patricia C. Weber "Application of Hydrogen/Deuterium-Exchange to p38 Mitogen-Activated Protein Kinase"
Amer. Biotechnol. Lab. 2007, February, 28.
James R. Horn, Brian Kraybill, Elizabeth J. Petro, Stephen J. Coales, Jeffrey A. Morrow, Yoshitomo Hamuro and Anthony A. Kossiakoff "The role of protein dynamics in increasing the binding affinity of an engineered protein-protein interaction established by H/D exchange mass spectrometry"
Biochemistry 2006, 45, 8488-8498.
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Yoshitomo Hamuro, Stephen J. Coales, Jeffrey A. Morrow, Kathleen S. Molnar, Steven J, Tuske, Mark R. Southern, and Patrick R. Griffin "Hydrogen/Deuterium-Exchange (H/D-Ex) of PPARγ LBD in the Presence of Various Modulators"
Protein Sci. 2006, 15, 1-10.
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Bomina Yu, William C. Edstrom, Yoshitomo Hamuro, Patricia C. Weber, Brian R. Gibney, and John Hunt "Crystal structure of catalytic complex of the Fe(II)-oxoglutarate-dependent DNA repair enzyme AlkB give insight into promiscuous substrate recognition and oxidation chemistry"
Nature 2006, 439, 879-884.
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Yoshitomo Hamuro (co-first authored), Lora L. Burns-Hamuro, Jack S. Kim, Paul Sigala, Rosa Fayos, David D. Stranz, Patricia A. Jennings, Susan S. Taylor, and Virgil L. Woods Jr. "Distinct Interaction Modes for an AKAP Bound to Two Regulatory Subunit Isoforms of PKA Revealed by Amide Hydrogen/Deuterium Exchange"
Protein Sci. 2005, 14, 2982-2992.
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Yoshitomo Hamuro, Patricia C. Weber and Patrick R. Griffin "High Throughput Analysis of Protein Structure by Hydrogen/Deuterium Exchange Mass Spectrometry" in
Industrial Proteomics Daniel Figeys Ed., Wiley, NY, 2005.
Yoshitomo Hamuro, Ganesh S. Anand, Jack S. Kim, Celina Juliano, David D. Stranz, Susan S. Taylor, and Virgil L. Woods Jr. "Mapping Intersubunit Interactions of the Regulatory Subunit (R
Iα? in the Type I Holoenzyme of Protein Kinase A by Enhanced Amide Hydrogen/Deuterium Exchange Mass Spectrometry (DXMS)"
J. Mol. Biol. 2004, 340, 1185-1196.
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Yoshitomo Hamuro, Stephen J. Coales, Mark R. Southern, Jennifer F. Nemeth-Cawley, David D. Stranz, and Patrick R. Griffin "Rapid Analysis of Protein Structure and Dynamics by Hydrogen/Deuterium Exchange Mass Spectrometry"
J. Biomol. Tech. 2003, 14, 171-182.
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Kerri M. Zawadzki, Yoshitomo Hamuro, Jack S. Kim, Siv Garrod, David D. Stranz, Susan S. Taylor, and Virgil L. Woods Jr. "Dissecting Interdomain Communication within cAPK Regulatory Subunit Type IIβ Using Enhanced Amide Hydrogen/Deuterium Exchange Mass Spectrometry (DXMS)"
Protein Sci. 2003, 12, 1980-1990.
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Joan J. Englander, Charyl Delmar, Will Li, S. Walter Englander, Jack S. Kim, David D. Stranz, Yoshitomo Hamuro and Virgil L. Woods, Jr. "Protein structure change studied by hydrogen-deuterium exchange, functional labeling, and mass spectrometry"
Proc. Natl. Acad. Sci. USA 2003, 100, 7057-7062.
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Yoshitomo Hamuro, Kerri M. Zawadzki, Jack S. Kim, David D. Stranz, Susan S. Taylor, and Virgil L. Woods Jr. "Dynamics of cAPK Type II? Activation Revealed by Enhanced Amide H/
2H Exchange Mass Spectrometry (DXMS)"
J. Mol. Biol. 2003, 327, 1065-1076.
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Yoshitomo Hamuro, Lilly Wong, Jennifer Shaffer, Jack S. Kim, David D. Stranz, Patricia A. Jennings, Virgil L. Woods Jr. and Joseph A. Adams "Phosphorylation-Driven Motions in the COOH-Terminal Src Kinase, Csk, Revealed Through Enhanced Hydrogen-Deuterium Exchange and Mass Spectrometric Studies (DXMS)" J. Mol. Biol. 2002, 323, 871-881.
Yoshitomo Hamuro, Lora L. Burns, Jaume M. Canaves, Ross C. Hoffman, Susan S. Taylor and Virgil L. Woods Jr. "Domain Organization of D-AKAP2 Revealed by Enhanced Deuterium Exchange-Mass Spectrometry (DXMS)"
J. Mol. Biol. 2002, ,321, 703-714.
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Virgil L. Woods Jr. and Yoshitomo Hamuro "High Resolution, High-Throughput Amide Deuterium Exchange-Mass Spectrometry (DXMS) Determination of Protein Binding Site Structure and Dynamics: Utility in Pharmaceutical Design" J. Cellular Biochem. Suppl. 2002, 37, 89-98.